The ensuing field of metallomics refers to the wholeness of research proceedings aimed at the assimilating of the molecular mechanisms of metal-dependent life processes. This censorious review scrutinize the concept of metallomics with a cynosure on analytical techniques and methods for the probing of interactions between metal ions and the organism's genome and the derived -omes: proteome and metabolome. Particular notice is bestow to the in vivo screening for the native metal-protein and metal-metabolite complexes by hyphenated techniques that combine a high-resolution separation technique (gel electrophoresis, chromatography or capillary electrophoresis) with sensitive elemental (inductively coupled plasma, ICP) or molecular mass spectrometric detection (electrospray or MALDI).
- Track 1-1 Gel Electrophoresis
- Track 2-2 Electrospray or MALDI
- Track 3-3 Inductively Coupled Plasma